{"id":5021,"date":"2023-03-31T21:37:05","date_gmt":"2023-03-31T21:37:05","guid":{"rendered":"https:\/\/www.ronniestanglermd.com\/?p=5021"},"modified":"2023-04-29T14:21:51","modified_gmt":"2023-04-29T14:21:51","slug":"reconsidering-treatment-resistant-depression","status":"publish","type":"post","link":"https:\/\/www.ronniestanglermd.com\/index.php\/2023\/03\/31\/reconsidering-treatment-resistant-depression\/","title":{"rendered":"Reconsidering Treatment-resistant Depression"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>excerpted from an article in The Conversation<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A plumber who shows up to fix a leaking toilet with a single tool is not likely to succeed. The same is true if a mental health professional offers only one approach for a complex problem like depression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Depression too often gets deemed &#8220;hard to treat&#8221; when medication falls&nbsp;short<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sadly, the number of people&nbsp;struggling with depression&nbsp;<a href=\"https:\/\/www.who.int\/news\/item\/02-03-2022-covid-19-pandemic-triggers-25-increase-in-prevalence-of-anxiety-and-depression-worldwide\">increased dramatically<\/a>&nbsp;at the height of the COVID-19 pandemic.&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.jad.2023.01.050\">Stress<\/a>&nbsp;\u2013 from school closures to job losses to the death of loved ones \u2013 made life more challenging and increased the risk of developing emotional difficulties. For some groups that have experienced discrimination,&nbsp;<a href=\"https:\/\/doi.org\/10.1007\/s40615-022-01284-9\">ongoing inequities<\/a>&nbsp;made their mental health even worse.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is a professional<a rel=\"noreferrer noopener\" href=\"https:\/\/muse.jhu.edu\/article\/236278\" target=\"_blank\"> debate<\/a> about&nbsp;whether depression is a social problem&nbsp;or a disease. Meanwhile, a 62% increase in&nbsp;yearly spending on U.S. mental health care, from US $131 billion in 2006 to $212 billion in 2015, has not led to the intended level of improvement for patients.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This makes it clear that the&nbsp;current approach is <a rel=\"noreferrer noopener\" href=\"https:\/\/www.hsph.harvard.edu\/ecpe\/why-leadership-in-mental-health-care-is-needed-now-more-than-ever-and-how-to-implement-change\/\" target=\"_blank\">falling short<\/a>, albeit there are a host of viable adjuncts for helping to treat patients who are suffering with depression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Our mission is to share knowledge and inform decisions.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors of this article are&nbsp;a&nbsp;<a href=\"https:\/\/scholar.google.com\/citations?hl=en&amp;user=LFOKsvwAAAAJ&amp;view_op=list_works&amp;sortby=pubdate\">health and biological psychologist<\/a>&nbsp;who treats hospitalized patients with depression and anxiety and a&nbsp;<a href=\"https:\/\/scholar.google.com\/citations?user=p3SsTKUAAAAJ&amp;hl=en&amp;oi=ao\">doctoral student in social work<\/a>&nbsp;studying how to improve the lives of socially isolated older adults.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As mental health professionals, they see the effects of the&nbsp;<a href=\"https:\/\/www.psychiatrictimes.com\/view\/mental-health-america-crisis\">ongoing mental health crisis<\/a>&nbsp;on a daily basis.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>An overreliance on medication causes harm<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">More than&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33054926\/\">13% of U.S. adults take an antidepressant medication<\/a>&nbsp;for depression or for other reasons.&nbsp;<a href=\"https:\/\/doi.org\/10.3389\/fpsyt.2019.00407\">Many people report feeling better<\/a>&nbsp;on antidepressants, though there is&nbsp;<a href=\"https:\/\/theconversation.com\/in-research-studies-and-in-real-life-placebos-have-a-powerful-healing-effect-on-the-body-and-mind-173845\">debate about what causes the improvements<\/a>.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Unfortunately, nearly 3 in 4 who take these drugs&nbsp;<a href=\"https:\/\/psycnet.apa.org\/doi\/10.1037\/cns0000261\">do not get complete relief from antidepressants<\/a>. As we discussed in a recent paper, people who do not feel better on antidepressants are usually categorized as having a&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.ssmmh.2022.100081\">difficult-to-treat type of depression<\/a>&nbsp;referred to, controversially, as \u201ctreatment-resistant depression.\u201d&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We see patients&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.psc.2011.11.004\">who feel demoralized<\/a>&nbsp;by the implied and untrue notion that their depression is \u201cincurable\u201d after only trying medication but not&nbsp;lower-risk treatments&nbsp;like psychotherapy and&nbsp;other potentially effective alternatives. We help them find hope again.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The U.S. health care system&nbsp;<a href=\"https:\/\/www.usnews.com\/news\/health-news\/articles\/2022-04-20\/in-long-run-antidepressants-dont-improve-quality-of-life-study\">relies heavily on medication<\/a>&nbsp;and other&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31612847\/\">biomedical treatments<\/a>&nbsp;for depression. But in fact there are numerous non-drug-based solutions for prevention and treatment of depression.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Holistic concepts that promote&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.ssmmh.2021.100052\">flourishing<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/doi.org\/10.1027\/1016-9040\/a000294\">thriving<\/a>, as well as&nbsp;<a href=\"https:\/\/www.va.gov\/wholehealth\/\">whole-health initiatives<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/doi.org\/10.1056%2FNEJMp1917461\">mind-body medicine<\/a>&nbsp;focus on the entire person. These concepts have not yet been fully integrated into approaches to public mental health.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The word \u2018heal\u2019 is derived from the same Latin and Greek words that mean \u2018whole.\u2019<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The quest to understand well-being and depression<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are many hardworking, highly successful people who do not feel fulfilled with life from time to time. When this internal lack of fulfillment also includes other symptoms like a loss of hope and becomes severe enough to disrupt daily life for a period of two weeks or more, it may be medically diagnosed as depression.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the 1960s, researchers proposed that&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.ssmmh.2022.100098\">depression was caused by a chemical imbalance<\/a>&nbsp;of a neurotransmitter called serotonin in the brain. In 1988, the pharmaceutical company Eli Lilly introduced&nbsp;<a href=\"https:\/\/doi.org\/10.1037%2Fa0038550\">an antidepressant medication based on that idea<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, after decades of experiments, researchers have failed to find evidence showing support for the chemical imbalance theory. A recent study highlights the&nbsp;<a href=\"https:\/\/www.ucl.ac.uk\/news\/2022\/aug\/opinion-chemical-imbalance-theory-depression-clearing-some-misconceptions\">growing realization that antidepressant medications<\/a>&nbsp;do not work&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/s41380-022-01661-0\">in the simplistic way<\/a>&nbsp;in which they&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3313530\/\">have been advertised<\/a>&nbsp;for decades.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is important because antidepressants have&nbsp;<a href=\"https:\/\/www.karger.com\/Article\/Abstract\/447034\">side effects<\/a>&nbsp;that can be serious. For a doctor and patient to weigh the risks and benefits of taking an antidepressant, they need accurate information about both. The chemical imbalance theory interfered with that conversation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tools to heal depression<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So what exactly does contribute to overall well-being and happiness to help stave off depression?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A large body of research shows that&nbsp;<a href=\"https:\/\/doi.org\/10.3390%2Fbrainsci11121633\">biological, psychological and social factors<\/a>&nbsp;contribute to feeling satisfied in life or to developing depression. Because each individual is unique, there is not a one-size-fits-all formula for well-being.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Many people find relief from depression by talking to a psychotherapist.&nbsp;<a href=\"https:\/\/doi.org\/10.1002%2Fwps.20238\">High-quality psychotherapy<\/a>&nbsp;has been shown to be as effective as and&nbsp;<a href=\"http:\/\/dx.doi.org\/10.1136\/bmjopen-2012-002542\">longer-lasting<\/a>&nbsp;<a href=\"https:\/\/doi.org\/10.1038%2Fnrn2345\">than antidepressant medication<\/a>&nbsp;when treating depression.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Therapy&nbsp;<a href=\"https:\/\/psycnet.apa.org\/record\/2017-55500-019\">activates an individual\u2019s hope<\/a>&nbsp;and natural resilience by&nbsp;<a href=\"https:\/\/doi.org\/10.3389\/fnint.2022.871227\">creating a safe<\/a> and emotionally warm relationship through which the therapist and client work together toward common goals. In addition to helping clients learn about their emotions, thoughts, relationships and patterns of behavior, a good therapist explores how to help their clients identify everyday activities that can improve wellness.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The things we do on a day-to-day basis, called&nbsp;<a href=\"https:\/\/doi.org\/10.1186\/1471-244x-14-107\">lifestyle factors<\/a>, function as building blocks for a life without depression.&nbsp;<a href=\"https:\/\/www.johnwbrickfoundation.org\/move-your-mental-health-report\/\">Physical movement<\/a>,&nbsp;<a href=\"https:\/\/www.health.harvard.edu\/blog\/diet-and-depression-2018022213309\">good nutrition<\/a>,&nbsp;<a href=\"https:\/\/www.nytimes.com\/2013\/11\/19\/health\/treating-insomnia-to-heal-depression.html\">healthy sleep<\/a>,&nbsp;<a href=\"https:\/\/www.apa.org\/topics\/mindfulness\/meditation\">healthy levels of stress<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/doi.org\/10.1037%2Fa0018555\">stress management<\/a>,&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.jad.2017.04.043\">social connection<\/a>,&nbsp;<a href=\"https:\/\/www.healthexperiencesusa.org\/Depression-in-Young-Adults\/having-a-purpose-in-life\">finding meaning and purpose<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/doi.org\/10.1007\/s11126-020-09881-9\">spiritual practices<\/a>&nbsp;all play important roles in preventing and treating depression.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Exercise is a powerful antidote against depression, anxiety and stress.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These are too often wrongly trivialized as less effective than professional treatment. In fact, though, a&nbsp;<a href=\"https:\/\/theconversation.com\/exercise-is-even-more-effective-than-counselling-or-medication-for-depression-but-how-much-do-you-need-200717\">recent study<\/a>&nbsp;showed that exercise may be&nbsp;<a href=\"http:\/\/dx.doi.org\/10.1136\/bjsports-2022-106195\">even more effective than medication or counseling<\/a>. Another study showed that&nbsp;<a href=\"https:\/\/doi.org\/10.1097\/01.nmd.0000217820.33841.53\">85% of people who received no treatment<\/a>&nbsp;still recovered from depression within one year.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As mental health professionals, we find these results both humbling and inspiring. It means that the general public has solutions for depression that the mental health system has too often overlooked. This is consistent with the&nbsp;<a href=\"https:\/\/www.ifm.org\/news-insights\/healing-works-means-health-care-wayne-jonas-md\/\">scientific study of healing<\/a>, which shows that the body has a tremendous and overlooked&nbsp;ability to repair and heal itself&nbsp;under the right circumstances.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hope comes in many forms<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One research initiative has identified communities,&nbsp;<a href=\"https:\/\/doi.org\/10.1177%2F1559827616637066\">called Blue Zones<\/a>, where people tend to live long, healthy and satisfying lives. The lifestyles of people living in these areas, like Ikaria, Greece, and Okinawa, Japan, are characterized by social connection, consumption of mostly plant-based foods, a high sense of purpose, environments that support physical movement and intentional relaxation. Customs in different countries and environments show that these principles are visible across the globe in many different forms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Many cultures extol the benefits of being in nature.&nbsp;<a href=\"https:\/\/www.bbc.com\/worklife\/article\/20171211-friluftsliv-the-nordic-concept-of-getting-outdoors\">Nordic countries use the word friluftsliv<\/a>, which means \u201coutdoor life,\u201d to describe the practice of getting outdoors to improve well-being. In Japan,&nbsp;some people practice <a href=\"https:\/\/www.japan.travel\/en\/guide\/forest-bathing\/\" target=\"_blank\" rel=\"noreferrer noopener\">shinrin-yoku<\/a>, translated as forest bathing or opening up the senses to&nbsp;<a href=\"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/revneuro-2015-0009\/html\">the natural world\u2019s scents<\/a>, sights and sounds.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers have also found that access to green space is associated with&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/www.mdpi.com\/1660-4601\/11\/3\/3453\" target=\"_blank\">lower depression levels<\/a>. Other studies&nbsp;show that gardening is linked with&nbsp;less depression, stronger social connections and improvement in quality of life. Gardening also gives those with access a chance to move their bodies and eat more homegrown vegetables as part of an&nbsp;anti-depression nutrition plan.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We cannot describe everything on the endless list of life-affirming, research-supported and low-risk methods to decrease stress, boost mood and enhance fulfillment. But here are a few more examples:&nbsp;aromatherapy;&nbsp;light therapy; yoga; music; art; gratitude practice; positive psychology; peer and social support programs. None of these are meant to be definitive treatments, but rather adjuncts. These seemingly simple interventions may be powerful when they lead to health-promoting psychological and&nbsp;physiological changes.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Staying true to what works<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Clinicians, researchers and&nbsp;<a href=\"https:\/\/www.wired.com\/2017\/05\/star-neuroscientist-tom-insel-leaves-google-spawned-verily-startup\/\">leaders<\/a>&nbsp;have been trying to identify the&nbsp;<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00021528\">best treatment for depression<\/a>&nbsp;for at least two decades.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is an unanswerable question. Some treatments work extremely well for certain people and cause terrible reactions for others. When&nbsp;<a href=\"http:\/\/dx.doi.org\/10.1136\/adc.2004.058222\">standard research protocols<\/a>&nbsp;try to capture these effects, it can&nbsp;look like there is <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0887-378X.2004.00327.x\" target=\"_blank\" rel=\"noreferrer noopener\">no effect <\/a>of the treatment&nbsp;because the positive effects average out with the negative effects.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A search for the holy grail of a&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0149763417303688?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">neurobiological cause<\/a> for depression&nbsp;has drawn attention away from efforts to implement what is already known about how to&nbsp;<a href=\"https:\/\/www.who.int\/europe\/about-us\/our-work\/core-priorities\/promoting-health-and-well-being\">promote health<\/a>.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To&nbsp;<a href=\"https:\/\/www.cdc.gov\/hrqol\/wellbeing.htm#one\">live one\u2019s best life<\/a>, everyone needs safety, shelter, clothing, good nutrition, good sleep, physical movement,&nbsp;<a href=\"https:\/\/doi.org\/10.1007\/s12671-020-01375-w\">loving kind social connection<\/a>&nbsp;and a sense of meaning and purpose. There are many ways to help people get there.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>excerpted from &#8220;<a rel=\"noreferrer noopener\" href=\"https:\/\/theconversation.com\/depression-too-often-gets-deemed-hard-to-treat-when-medication-falls-short-198282?utm_medium=email&amp;utm_campaign=Latest%20from%20The%20Conversation%20for%20March%2015%202023%20-%202570925852&amp;utm_content=Latest%20from%20The%20Conversation%20for%20March%2015%202023%20-%202570925852+CID_0109e87994a0c49b945865a86097edf0&amp;utm_source=campaign_monitor_us&amp;utm_term=Depression%20too%20often%20gets%20deemed%20hard%20to%20treat%20when%20medication%20falls%20short\" target=\"_blank\">Depression too often gets deemed &#8216;hard to treat&#8217; when medication falls&nbsp;short<\/a>&#8221; by E. Patterson and J. Kayser, published online in The Conversation, March 15, 2023<\/em><\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center wp-block-paragraph\"><a href=\"https:\/\/www.ronniestanglermd.com\/index.php\/2023\/04\/07\/hydration-linked-to-longer-healthier-life\/\">previous<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center wp-block-paragraph\"><a href=\"https:\/\/www.ronniestanglermd.com\/index.php\/2023\/03\/19\/on-pets-moral-logic-and-love\/\">next<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>excerpted from an article in The Conversation A plumber who shows up to fix a leaking toilet with a single tool is not likely to succeed. The same is true if a mental health professional offers only one approach for a complex problem like depression. Depression too often gets deemed &#8220;hard to treat&#8221; when medication&hellip;<\/p>\n","protected":false},"author":1,"featured_media":5023,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[231],"tags":[],"class_list":["post-5021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-good-reads"],"_links":{"self":[{"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/posts\/5021","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/comments?post=5021"}],"version-history":[{"count":10,"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/posts\/5021\/revisions"}],"predecessor-version":[{"id":6196,"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/posts\/5021\/revisions\/6196"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/media\/5023"}],"wp:attachment":[{"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/media?parent=5021"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/categories?post=5021"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ronniestanglermd.com\/index.php\/wp-json\/wp\/v2\/tags?post=5021"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}